Research Highlights

The research in the Han Lab is directed to understand the molecular mechanisms of genetic diseases affecting the neuromuscular system, and to develop novel therapeutic strategies to combat these devastating diseases.

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Nature Communications

Systemic Delivery of Full-Length Dystrophin in Duchenne Muscular Dystrophy Mice.

Zhou R, Zhang C, Xiao W, Herzog RW, Han R.
2024

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Molecular Therapy - Nucleic Acids

Targeting miR-25 to Alleviate DMD-Related Muscle Dysfunction.

Li S, Han R.
2024

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Molecular Therapy - Nucleic Acids

Base editing in humanized dystrophic mice.

Zhang C, Zhou Y, Han R.
2024

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Nature Communications

Defective BVES-mediated feedback control of cAMP in muscular dystrophy.

Li H, Wang P, Zhang C, Zuo Y, Zhou Y, Han R.
2023

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Cell & Bioscience

Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice.

Zuo Y, Zhang C, Zhou Y, Li H, Xiao W, Herzog RW, Xu J, Zhang J, Chen EY, Han R.
2023

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Molecular Therapy - Methods & Clinical Development

Correction of DMD in human iPSC-derived cardiomyocytes by base editing-induced exon skipping.

Wang P, Li H, Zhu M, Han RY, Guo S, Han R.
2022

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Molecular Therapy

Systemic AAV9.BVES Delivery Ameliorates Muscular Dystrophy in a Mouse Model of LGMDR25.

Li H, Wang P, Hsu E, Pinckard KM, Stanford KI and Han R.
2022

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Cell & Bioscience

BVES Is a Novel Interactor of ANO5 and Regulates Myoblast Differentiation.

Li H, Xu L, Gao Y, Zuo Y, Yang Z, Zhao L, Chen Z, Guo J, Han R.
2021

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Molecular Cancer

MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer.

Li H, Lin P-H, Pranav G, Li X, Zhao L, Zhou X, Li Z, Wei S, Xu L, Han R, Lu J, Tan T, Yang D-H, Chen Z-S, Pawlik TM, Merritt RE, Ma J
2021

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Cell & Bioscience

Pathological alterations in the gastrointestinal tract of a porcine model of DMD.

Zou X, Ouyang H, Pang D, Han R* and Tang X*.
2021

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Nature Communications

Efficient precise in vivo base editing in adult dystrophic mice.

Xu L, Zhang C, Li H, Wang P, Gao Y, Mokadam NA, Ma J, Arnold WD, Han R.
2021

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Circulation Research

In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice.

El Refaey M, Xu L, Gao Y, Canan BD, Adesanya TMA, Warner SC, Akagi K, Symer DE, Mohler PJ, Ma J, Janssen PML, Han R.
2017

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Molecular Therapy

CRISPR-mediated Genome Editing Restores Dystrophin Expression and Function in mdx Mice.

Xu L, Park KH, Zhao L, Xu J, El Refaey M, Gao Y, Zhu H, Ma J, Han R.
2015

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Nature Medicine

The intracellular Ca2+ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.

Cheng X, Zhang X, Gao Q, Ali Samie M, Azar M, Tsang WL, Dong L, Sahoo N, Li X, Zhuo Y, Garrity AG, Wang X, Ferrer M, Dowling J, Xu L, Han R, Xu H.
2014

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Immunity

Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation.

Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, Eisenbarth SC, Nauseef WM, Cassel SL, Sutterwala FS.
2013

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Nature Communations

TRPM2 links oxidative stress to NLRP3 inflammasome activation.

Zhong Z, Zhai Y, Liang S, Mori Y, Han R, Sutterwala FS, Qiao L.
2013

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J Clin Invest

Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient mice.

Han R, Frett EM, Levy JR, Rader EP, Lueck JD, Bansal D, Moore SA, Ng R, Beltran-Valero de Bernabe D, Faulkner JA, Campbell KP.
2010

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PNAS

Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of alpha-dystroglycan.

Han R, Kanagawa M, Yoshida-Moriguchi T, Rader EP, Ng RA, Michele DE, Muirhead DE, Kunz S, Moore SA, Iannaccone ST, Miyake K, McNeil PL, Mayer U, Oldstone MB, Faulkner JA, Campbell KP.
2009

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J Clin Invest

Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injury.

Han R, Bansal D, Miyake K, Muniz VP, Weiss RM, McNeil PL, Campbell KP.
2007