Click below to download the BEAT program for offline usage running on your computer:
Windows ||
Mac
Please cite: Xu L, Liu Y, Han R. (2019) BEAT: A python program to quantify base editing from Sanger sequencing. CRISPR J 2(4):223-229.
Cited by:
- Rothgangl T, Dennis M, et al., In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels. Nature Biotechnology, 2021
- Huang C, Li G, Wu J, Liang J, Wang X. Identification of pathogenic variants in cancer genes using base editing screens with editing efficiency correction. Genome Biology 2021.
- Xu L, Zhang C, et al., Efficient precise in vivo base editing in adult dystrophic mice . Nature Communications, 2021
- KA Molla, S Sretenovic, KC Bansal, Y Qi, Precise plant genome editing using base editors and prime editors . Nature Plants, 2021
IMPORTANT: The sequencing data is usually noisy in the beginning and at the end. You will need to set proper values for the Start and End positions in your sequencing data to be included for BEAT analysis.
05/21/2021: Fixed an issue caused by special characters in file names.
06/20/2024: If you could not run the offline program on your macOS, please try the following:
- Open a terminal window;
- Using the cd command, navigate to the place where the application is stored: cd path_to_application;
- Run sudo chmod +x application_file to make it executable. The command should look something like this:
sudo chmod +x "/Applications/Beat_OSX.app/Contents/MacOS/Beat_OSX"